Isopropylamine → 2-acetamido-4-(N-isopropylamino)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine

HRID 1025519ノート

反応式

HRID 1025519 の反応式
[C:1]([NH:4][C:5]1[N:6]=[C:7](C2N=CNN=2)[C:8]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH:12]=[CH:11][C:9]=2[N:10]=1)(=[O:3])[CH3:2].[CH:27]([NH2:30])([CH3:29])[CH3:28]>O1CCOCC1>[C:1]([NH:4][C:5]1[N:6]=[C:7]([NH:30][CH:27]([CH3:29])[CH3:28])[C:8]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH:12]=[CH:11][C:9]=2[N:10]=1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 6363IsopropylamineHCID 178474430HCID 178474430、化合物

生成物 1

HCID 690791042-acetamido-4-(N-isopropylamino)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine収率 73%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a suspension of the 2-acetamido-4-(1,2,4-triazolyl)-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine of example 2 (70 mg) in dioxane (5 ml) was added isopropylamine (0.4 mmol). The reaction was stirred at room temperature for 24 hours. The solvents were evaporated in vacuo, yielding the crude title compound which was purified by preparative TLC on silica, using a mixture of methanol and dichloromethane, in a ratio of 10:90 as mobile phase, thus providing the title compound in 73% yield. The pure title compound was characterized by its mass spectrum as follows: MS (m/z): 340 ([M+H]+, 100).

後処理

  1. customThe solvents were evaporated in vacuo
  2. customyielding the crude title compound which
  3. customwas purified by preparative TLC on silica
  4. additiona mixture of methanol and dichloromethane

出典と根拠

ORDレコード
ord-9255a2db6ce149ababd4486365ebb536
出典データセット
uspto-grants-2014_05
特許番号
US08729089B2

反応ノート

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