Isopropylamine → HCID 86621818、化合物

HRID 1025528

反応式

HRID 1025528 の反応式
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1.[CH:20]([NH2:23])([CH3:22])[CH3:21].[CH:24]1([NH2:27])[CH2:26][CH2:25]1>C1OCCCO1>[Cl:1][C:2]1[N:3]=[C:4]([NH:23][CH:20]([CH3:22])[CH3:21])[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1.[Cl:1][C:2]1[N:3]=[C:4]([NH:27][CH:24]2[CH2:26][CH2:25]2)[C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:6]=2[N:7]=1

参加物

6

反応物 3

HCID 6363IsopropylamineHCID 69828CyclopropylamineHCID 596478432,4-Dichloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine

生成物 2

HCID 86621818HCID 86621818、化合物HCID 86621819HCID 86621819、化合物

試薬・触媒・溶媒 1

HCID 104501,3-Dioxane溶媒

実験手順

The procedure used in the first step was as follows: a mixture of 2,4-dichloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine (2.0 g), isopropylamine (2 ml) or cyclopropylamine (2 ml) in 2,6-dioxane (20 mL) was stirred for 1 hour. Solvents were concentrated in vacuo and the residue was dissolved in DCM (20 ml). The solid was filtered to provide 2-chloro-6-(4-fluorophenyl)-N-isopropylpyrido[3,2-d]pyrimidin-4-amine and 2-chloro-6-(4-fluorophenyl)-N-cyclopropylpyrido[3,2-d]pyrimidin-4-amine respectively, which were characterized by their mass spectra as follows: MS (m/z) 317 [M+H]+ and MS (m/z) 315 [M+H]+, respectively.

後処理

  1. concentrationSolvents were concentrated in vacuo
  2. dissolutionthe residue was dissolved in DCM (20 ml)
  3. filtrationThe solid was filtered

出典と根拠

ORDレコード
ord-8b2341671f98494195476fa6ab74ff12
出典データセット
uspto-grants-2014_05
特許番号
US08729089B2

関連ノート

読み込み中…