cis-1,2,3,6-Tetrahydrophthalimide → 1H-Isoindole-1,3(2H)-dione, hexahydro-

HRID 1025539

反応式

HRID 1025539 の反応式
[C:1]1(=[O:11])[C@@H:9]2[C@@H:4]([CH2:5][CH:6]=[CH:7][CH2:8]2)[C:3](=[O:10])[NH:2]1>CO.[Pd]>[C:1]1(=[O:11])[CH:9]2[CH:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[C:3](=[O:10])[NH:2]1

参加物

4

反応物 1

HCID 92888cis-1,2,3,6-Tetrahydrophthalimide

生成物 1

HCID 735591H-Isoindole-1,3(2H)-dione, hexahydro-収率 85.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of (3aR,7aS)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione (3.0 g, 19.9 mmol) and 10% Pd/C (300 mg) in MeOH (100 mL) was shaken in an H2 atmosphere (300 psi) in a Parr apparatus for 24 h. The reaction mixture was filtrated and the liquids concentrated to dryness, affording the title compound (2.6 g, 16.99 mmol), that was sued without any further purification, as a white powder.

後処理

  1. filtrationThe reaction mixture was filtrated
  2. concentrationthe liquids concentrated to dryness

出典と根拠

ORDレコード
ord-eebc4f521baf4b0f85da8ce609a1ac54
出典データセット
uspto-grants-2014_05
特許番号
US08729098B2

関連ノート

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