(E)-4-(4-Fluoro-phenyl)-4-methyl-pent-2-enoic acid ethyl ester → 4-(4-Fluoro-phenyl)-4-methyl-pentanoic acid ethyl ester
反応式
[CH2:1]([O:3][C:4](=[O:17])/[CH:5]=[CH:6]/[C:7]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1)([CH3:9])[CH3:8])[CH3:2]>CO.[Pt](=O)=O>[CH2:1]([O:3][C:4](=[O:17])[CH2:5][CH2:6][C:7]([C:10]1[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=1)([CH3:9])[CH3:8])[CH3:2]参加物
4
実験手順
To a solution of (E)-4-(4-fluoro-phenyl)-4-methyl-pent-2-enoic acid ethyl ester (4.10 g) in methanol (150 ml) at room temperature was added platinum(IV) oxide (788 mg). The mixture was stirred under an atmosphere of hydrogen (1 atm) at room temperature for 2 h. The catalyst was removed by filtration and the filtrate was concentrated in vacuo to yield a yellow oil, (3.97 g, 96%); MS (ISP): 239.2 ([M+H]+).
後処理
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated in vacuo
- customto yield a yellow oil, (3.97 g, 96%)
出典と根拠
- ORDレコード
- ord-4026d0ab01924658947eebdb4f517109
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08729113B2
反応ノート
読み込み中…