4-Amino-3-nitrobenzimidamide hydrochloride → 3,4-Diaminobenzimidamide hydrochloride

HRID 1026196ノート

反応式

HRID 1026196 の反応式
[ClH:1].[NH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[NH:8])=[CH:5][C:4]=1[N+:12]([O-])=O>[OH-].[OH-].[Pd+2].CO>[ClH:1].[NH2:12][C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:3]=1[NH2:2])[C:7]([NH2:9])=[NH:8]

参加物

4

反応物 1

HCID 673560924-Amino-3-nitrobenzimidamide hydrochloride

生成物 1

HCID 221255323,4-Diaminobenzimidamide hydrochloride

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒2 回HCID 887Methanol溶媒

実験手順

A suspension of 4-amino-3-nitrobenzamidine monohydrochloride (15 g, 69 mmol) and Pearlman's catalyst [Pd(OH)2, 1.0 g, 7.12 mmol) in methanol (200 mL) was shaken under hydrogen atmosphere 50 psi for 1.5 h. The suspension was filtered through Celite and the filtrate was added dropwise to anhydrous diethyl ether (400 mL) to precipitate 3,4-diaminobenzamidine monohydrochloride as a tan solid.

後処理

  1. filtrationThe suspension was filtered through Celite
  2. additionthe filtrate was added dropwise to anhydrous diethyl ether (400 mL)
  3. customto precipitate 3,4-diaminobenzamidine monohydrochloride as a tan solid

出典と根拠

ORDレコード
ord-ff68b3688fc54bdbb19cd8204f84dc29
出典データセット
uspto-grants-2014_05
特許番号
US08729117B2

反応ノート

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