Diisopropylethylamine → (S)-tert-butyl 1-(((2-(7-(4-(3-(2,4-difluorophenyl)ureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-1-methyl-1H-imidazol-5-yl)methyl)(2-methoxyethyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate

反応式

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][C:20]2[CH:25]=[CH:24][N:23]=[C:22]3[CH:26]=[C:27]([C:29]4[N:30]([CH3:40])[C:31]([CH2:34][NH:35][CH2:36][CH2:37][O:38][CH3:39])=[CH:32][N:33]=4)[S:28][C:21]=23)=[C:15]([F:41])[CH:14]=1)=[O:11].[C:42]([O:46][C:47]([NH:49][C@@H:50]([CH:54]([CH3:56])[CH3:55])[C:51](O)=[O:52])=[O:48])([CH3:45])([CH3:44])[CH3:43].CCN(C(C)C)C(C)C.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>CN(C=O)C.CCOC(C)=O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10](=[O:11])[NH:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][C:20]2[CH:25]=[CH:24][N:23]=[C:22]3[CH:26]=[C:27]([C:29]4[N:30]([CH3:40])[C:31]([CH2:34][N:35]([CH2:36][CH2:37][O:38][CH3:39])[C:51](=[O:52])[C@@H:50]([NH:49][C:47](=[O:48])[O:46][C:42]([CH3:45])([CH3:44])[CH3:43])[CH:54]([CH3:56])[CH3:55])=[CH:32][N:33]=4)[S:28][C:21]=23)=[C:15]([F:41])[CH:14]=1