Triethylamine → Methanesulfonic acid (S)-3-(4-benzyloxycarbonylamino-phenyl)cyclopentyl ester

HRID 1027402ノート

反応式

HRID 1027402 の反応式
[CH2:1]([O:8][C:9](=[O:23])[NH:10][C:11]1[CH:16]=[CH:15][C:14]([C@H:17]2[CH2:21][CH2:20][CH:19]([OH:22])[CH2:18]2)=[CH:13][CH:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CCN(CC)CC.[CH3:31][S:32](Cl)(=[O:34])=[O:33].CCOC(C)=O>C(Cl)Cl.CCCCCCC>[CH2:1]([O:8][C:9]([NH:10][C:11]1[CH:12]=[CH:13][C:14]([CH:17]2[CH2:21][CH2:20][C@H:19]([O:22][S:32]([CH3:31])(=[O:34])=[O:33])[CH2:18]2)=[CH:15][CH:16]=1)=[O:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

7

反応物 4

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 31297Methanesulfonyl chlorideHCID 67479260[4-((S)-3-Hydroxy-cyclopentyl)-phenyl]-carbamic acid benzyl ester

生成物 1

HCID 86678094Methanesulfonic acid (S)-3-(4-benzyloxycarbonylamino-phenyl)cyclopentyl ester収率 93.5%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒2 回HCID 8900Heptane溶媒

実験手順

To a solution of [4-((S)-3-hydroxy-cyclopentyl)-phenyl]-carbamic acid benzyl ester (0.44 g, 1.4 mmol) in DCM (8 mL) was added Et3N (214 mg, 0.3 mL, 2.12 mmol, 1.5 equiv.). The solution was cooled in an ice-water bath and then de-aerated by vacuum/nitrogen exchange. To this solution was transferred a solution of methanesulfonyl chloride (242 mg, 2.12 mmol, 1.5 equiv.) in DCM (2 mL). The clear solution was stirred with the ice-water bath on all the time for 1 h. TLC (50% EtOAc in heptane) indicated that the reaction was complete. The reaction was quenched by diluting with DCM (10 mL), followed by addition of NaHCO3 aq. (5 mL). The two layers were separated and the aqueous layer was extracted with DCM (2×5 mL). The combined extracts were washed successively with NaHCO3 aq. (5 mL), brine (5 mL) and dried (K2CO3). The solution was filtered through a silica gel pad, eluted with 5% MeOH in DCM. The filtrate was concentrated to dryness to obtain 510 mg (yield: 93%) of the title compound as an off-white wax-like solid material.

後処理

  1. temperatureThe solution was cooled in an ice-water bath
  2. customThe reaction was quenched
  3. additionby diluting with DCM (10 mL)
  4. additionfollowed by addition of NaHCO3 aq. (5 mL)
  5. customThe two layers were separated
  6. extractionthe aqueous layer was extracted with DCM (2×5 mL)
  7. washThe combined extracts were washed successively with NaHCO3 aq. (5 mL), brine (5 mL)
  8. dry with materialdried (K2CO3)
  9. filtrationThe solution was filtered through a silica gel pad
  10. washeluted with 5% MeOH in DCM
  11. concentrationThe filtrate was concentrated to dryness

出典と根拠

ORDレコード
ord-436a0de748924a38959a416a9f3f370d
出典データセット
uspto-grants-2014_05
特許番号
US08735385B2

反応ノート

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