Bromine → (S)-6-(4-bromo-3-cyano-1-cyclobutyl-6 (difluoromethoxy)-5-fluoro-1H-indol-2-yl)-N-(1,1,1-trifluoropropan-2-yl)pyridine-3-sulfonamide

反応式

[C:1]([C:3]1[C:11]2[C:6](=[CH:7][C:8]([O:13][CH:14]([F:16])[F:15])=[C:9]([F:12])[CH:10]=2)[N:5]([CH:17]2[CH2:20][CH2:19][CH2:18]2)[C:4]=1[C:21]1[N:26]=[CH:25][C:24]([S:27]([NH:30][C@@H:31]([CH3:36])[C:32]([F:35])([F:34])[F:33])(=[O:29])=[O:28])=[CH:23][CH:22]=1)#[N:2].[Br:37]Br.OS([O-])=O.[Na+]>[Fe].ClCCCl>[Br:37][C:10]1[C:9]([F:12])=[C:8]([O:13][CH:14]([F:15])[F:16])[CH:7]=[C:6]2[C:11]=1[C:3]([C:1]#[N:2])=[C:4]([C:21]1[N:26]=[CH:25][C:24]([S:27]([NH:30][C@@H:31]([CH3:36])[C:32]([F:34])([F:35])[F:33])(=[O:28])=[O:29])=[CH:23][CH:22]=1)[N:5]2[CH:17]1[CH2:18][CH2:19][CH2:20]1