Pyridine → N-(3-bromo-5-nitrophenyl)acetamide

HRID 1028102

反応式

HRID 1028102 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([N+:9]([O-:11])=[O:10])[CH:8]=1)[NH2:5].N1C=CC=CC=1.[C:18](Cl)(=[O:20])[CH3:19]>ClCCl.O>[Br:1][C:2]1[CH:3]=[C:4]([NH:5][C:18](=[O:20])[CH3:19])[CH:6]=[C:7]([N+:9]([O-:11])=[O:10])[CH:8]=1

参加物

6

反応物 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 44535ar-Bromo-ar-nitrobenzenamine

生成物 1

HCID 10658908N-(3-bromo-5-nitrophenyl)acetamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

3-Bromo-5-nitroaniline (6.45 g, 29.7 mmol) was dissolved in dichloromethane (149 mL) and pyridine (2.88 mL, 35.7 mmol). The solution was cooled to 0° C. and then, acetyl chloride (2.325 mL, 32.7 mmol) was added dropwise. The reaction mixture was stirred at 0° C. for 1 hour. The reaction was diluted with water and dichloromethane and the organic phase was dried over sodium sulfate and was concentrated to dryness. N-(3-bromo-5-nitrophenyl)acetamide was isolated as a beige powder (7.86 g, 30 mmol, 100%) and was of sufficient purity to carry forward without further purification.

後処理

  1. dry with materialthe organic phase was dried over sodium sulfate
  2. concentrationwas concentrated to dryness

出典と根拠

ORDレコード
ord-70ec7c4f20d74ae5b7511b8de2beb47a
出典データセット
uspto-grants-2014_05
特許番号
US08735417B2

関連ノート

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