1,4-Butanediol → 4-Hydroxybutyl ethyl(2-cyano-2-methylethyl)phosphinate
反応式
[CH2:1]([P:3]([CH2:6][CH:7]([C:9]#[N:10])[CH3:8])(=[O:5])[OH:4])[CH3:2].[CH2:11](O)[CH2:12][CH2:13][CH2:14][OH:15]>C1(C)C=CC=CC=1>[CH2:1]([P:3]([CH2:6][CH:7]([C:9]#[N:10])[CH3:8])(=[O:4])[O:5][CH2:11][CH2:12][CH2:13][CH2:14][OH:15])[CH3:2]参加物
4
実験手順
540 g (3.0 mol) of ethyl(2-cyano-2-methylethyl)phosphinic acid (produced as in Example 6) are at 80° C. dissolved in 400 ml of toluene and admixed with 315 g (3.5 mol) of 1,4-butanediol and esterified at about 100° C. during 4 h in a distillation apparatus equipped with a water trap. After the esterification has ended, the toluene is separated off in vacuo to leave 643 g (92% of theory) of 4-hydroxybutyl ethyl(2-cyano-2-methylethyl)phosphinate as colorless oil.
後処理
- customare at 80° C.
- customequipped with a water trap
- customthe toluene is separated off in vacuo
出典と根拠
- ORDレコード
- ord-1dc325450d6c4d39a2b96390db60d7c0
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08735477B2
反応ノート
読み込み中…