Ethanolamine → 4(3H)-Quinazolinone, 2-ethyl-3-(2-hydroxyethyl)-

HRID 1028345ノート

反応式

HRID 1028345 の反応式
[CH2:1]([C:3]1O[C:7](=[O:9])[C:6]2[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=2[N:4]=1)[CH3:2].[CH2:14]([CH2:16][NH2:17])[OH:15]>>[CH2:1]([C:3]1[N:17]([CH2:16][CH2:14][OH:15])[C:7](=[O:9])[C:6]2[C:5](=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:4]=1)[CH3:2]

参加物

3

反応物 2

HCID 700EthanolamineHCID 9285262-Ethyl-benzo[d][1,3]oxazin-4-one

生成物 1

HCID 103760834(3H)-Quinazolinone, 2-ethyl-3-(2-hydroxyethyl)-

反応条件

温度
100 °C

実験手順

1 g of 2-ethyl-4H-3,1-benzoxazin-4-one was added to 10 mL of monoethanolamine and the mixture was heated to 100° C. for 40 minutes. The heating element was then removed and the reaction medium was kept under agitation for about eight hours (end of the reaction). 100 mL were added to the reaction medium and the mixture was extracted with three portions of 25 mL of ethyl acetate. The organic phase was separated, and dried with magnesium sulfate and spin dried, yielding the 2-ethyl-3-(2-hydroxyethyl)quinazoline-4 (3H)-one compound as a yellowish oil, which solidified when left to rest at room temperature, which was used in the next stage, with no purification.

後処理

  1. customThe heating element was then removed
  2. custom(end of the reaction)
  3. addition100 mL were added to the reaction medium
  4. extractionthe mixture was extracted with three portions of 25 mL of ethyl acetate
  5. customThe organic phase was separated
  6. dry with materialdried with magnesium sulfate
  7. customspin dried

出典と根拠

ORDレコード
ord-a3dd176005d44bf7a359942665500fdc
出典データセット
uspto-grants-2014_05
特許番号
US08735578B2

反応ノート

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