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Potassium Carbonate → N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-3-(2-chloro-pyrimidin-4-yloxy)-4-methyl-benzamide

HRID 1028425
ノート
印刷プレビュー

反応式

HRID 1028425 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].[C:15]([C:19]1[CH:20]=[C:21]([NH:38][S:39]([CH3:42])(=[O:41])=[O:40])[C:22]([O:36][CH3:37])=[C:23]([NH:25][C:26](=[O:35])[C:27]2[CH:32]=[CH:31][C:30]([CH3:33])=[C:29]([OH:34])[CH:28]=2)[CH:24]=1)([CH3:18])([CH3:17])[CH3:16]>C(#N)C.CN(C)C=O.O>[C:15]([C:19]1[CH:20]=[C:21]([NH:38][S:39]([CH3:42])(=[O:41])=[O:40])[C:22]([O:36][CH3:37])=[C:23]([NH:25][C:26](=[O:35])[C:27]2[CH:32]=[CH:31][C:30]([CH3:33])=[C:29]([O:34][C:6]3[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=3)[CH:28]=2)[CH:24]=1)([CH3:18])([CH3:16])[CH3:17]
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 3

HCID 11430Potassium CarbonateHCID 775312,4-Dichloropyrimidine2 回HCID 67217566N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-3-hydroxy-4-methyl-benzamide

生成物 1

HCID 86664518N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-3-(2-chloro-pyrimidin-4-yloxy)-4-methyl-benzamide

試薬・触媒・溶媒 3

HCID 962Water
溶媒
HCID 6228Dimethylformamide溶媒
HCID 6342Acetonitrile溶媒

実験手順

567 mg 2,4-dichloropyrimidine and 663 mg potassium carbonate are added to 1.50 g N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-3-hydroxy-4-methyl-benzamide in 15 ml acetonitrile and 3 ml N,N-dimethylformamide, and the reaction mixture is stirred overnight at ambient temperature. Then another 57 mg 2,4-dichloropyrimidine are added, and the mixture is stirred for a further hour at ambient temperature. For working up the reaction mixture is diluted with water and the white precipitate formed is filtered off, washed with water and dried in the desiccator.

後処理

  1. stirringthe mixture is stirred for a further hour at ambient temperature
  2. customthe white precipitate formed
  3. filtrationis filtered off
  4. washwashed with water
  5. customdried in the desiccator

出典と根拠

ORDレコード
ord-7cb204f5f0d445449d6e97f4edbe4e51
出典データセット
uspto-grants-2014_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08735579B2

反応ノート

読み込み中…

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