Oxalyl chloride → 2-Bromo-3-methylbenzoyl chloride

HRID 1028940

反応式

HRID 1028940 の反応式
[Br:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].C(Cl)(=O)C([Cl:15])=O>C(Cl)Cl>[Br:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:15])=[O:5]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 27355882-Bromo-3-methylbenzoic acid

生成物 1

HCID 141743752-Bromo-3-methylbenzoyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

A suspension of 2-bromo-3-methylbenzoic acid (2.07 g, 9.63 mmol) in DCM (48.1 mL) was cooled to 0° C. Oxalyl chloride (0.9 mL, 10.14 mmol) was added dropwise via syringe. After addition, the cooling bath was removed and the reaction mixture stirred overnight. The mixture was concentrated in vacuo to remove solvent and excess reagent, affording 2-bromo-3-methylbenzoyl chloride as a cloudy white oil.

後処理

  1. additionAfter addition
  2. customthe cooling bath was removed
  3. concentrationThe mixture was concentrated in vacuo
  4. customto remove solvent and excess reagent

出典と根拠

ORDレコード
ord-83032d37c54a46f5b993f92c72bb64b3
出典データセット
uspto-grants-2014_05
特許番号
US08735384B2

関連ノート

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