5-Methylhexanoyl chloride → 2-(7-Methyl-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 5-methylhexanoate

HRID 1029509

反応式

HRID 1029509 の反応式
[CH3:1][C:2]1[N:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([N:12]3[CH:20]([OH:21])[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[C:13]3=[O:22])=[N:9]2)=[CH:4][CH:3]=1.[CH3:23][CH:24]([CH3:31])[CH2:25][CH2:26][CH2:27][C:28](Cl)=[O:29]>C(N(CC)CC)C>[CH3:23][CH:24]([CH3:31])[CH2:25][CH2:26][CH2:27][C:28]([O:22][CH:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:20](=[O:21])[N:12]1[C:8]1[CH:7]=[CH:6][C:5]2[C:10](=[N:11][C:2]([CH3:1])=[CH:3][CH:4]=2)[N:9]=1)=[O:29]

参加物

4

反応物 2

HCID 136648655-Methylhexanoyl chlorideHCID 199004392-(7-Methyl-1,8-naphthyridin-2-yl)-3-hydroxy-1-isoindolinone

生成物 1

HCID 700571562-(7-Methyl-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 5-methylhexanoate収率 74.2%

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

The procedure is as in example 7, but starting with 2-(7-methyl-1,8-naphthyridin-2-yl)-3-hydroxy-1-isoindolinone (3.7 g), 5-methylhexanoyl chloride (7.8 g), triethylamine (12 cc) and 4-diemthylaminopyridine (50 mg). After the solid obtained after treatment has been recrystallized in methylcyclohexane, 2-(7-methyl-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 5-methylhexanoate (3.8 g), m.p. 144° C., is obtained.

後処理

  1. customAfter the solid obtained after treatment
  2. customhas been recrystallized in methylcyclohexane

出典と根拠

ORDレコード
ord-1c52e89755fa4372a03b57242696e688
出典データセット
uspto-grants-1992_04
特許番号
US05102890

関連ノート

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