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5-Methylhexanoyl chloride → 2-(7-Methyl-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 5-methylhexanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Methylhexanoyl chloride | HCID 13664865 | — |
| 反応物 | 2-(7-Methyl-1,8-naphthyridin-2-yl)-3-hydroxy-1-isoindolinone | HCID 19900439 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 2-(7-Methyl-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 5-methylhexanoate | HCID 70057156 | 74.2% |
反応手順
The procedure is as in example 7, but starting with 2-(7-methyl-1,8-naphthyridin-2-yl)-3-hydroxy-1-isoindolinone (3.7 g), 5-methylhexanoyl chloride (7.8 g), triethylamine (12 cc) and 4-diemthylaminopyridine (50 mg). After the solid obtained after treatment has been recrystallized in methylcyclohexane, 2-(7-methyl-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 5-methylhexanoate (3.8 g), m.p. 144° C., is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05102890 |
| 出典データセット | uspto-grants-1992_04 |
| ORD ID | ord-1c52e89755fa4372a03b57242696e688 |
| 出典メモ | uspto-grants-1992_04 |