反应详情

The procedure is as in example 7, but starting with 2-(7-methyl-1,8-naphthyridin-2-yl)-3-hydroxy-1-isoindolinone (3.7 g), 5-methylhexanoyl chloride (7.8 g), triethylamine (12 cc) and 4-diemthylaminopyridine (50 mg). After the solid obtained after treatment has been recrystallized in methylcyclohexane, 2-(7-methyl-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl 5-methylhexanoate (3.8 g), m.p. 144° C., is obtained.

1. customAfter the solid obtained after treatment
2. customhas been recrystallized in methylcyclohexane