Hydrochloric Acid → 2-Methyl-4-methoxy-5-nitrophenol
反応式
S([O:5][C:6]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[C:9]([O:15][CH3:16])=[CH:8][C:7]=1[CH3:17])(=O)(=O)C.[OH-].[Na+].Cl>CO.O>[CH3:17][C:7]1[CH:8]=[C:9]([O:15][CH3:16])[C:10]([N+:12]([O-:14])=[O:13])=[CH:11][C:6]=1[OH:5]参加物
6
実験手順
In 110 ml of methanol was dissolved 15.5 g (59.4 mmol) of 2-methyl-4-methoxy-5-nitropheyl mesylate. Then 6.5 g of sodium hydroxide dissolved in 20 ml of water was added thereto. The obtained mixture was heated under reflux for 1 hour. After cooling, concentrated hydrochloric acid was added to thereby acidify the mixture. Then 400 ml of water was added and crystals were precipitated. The crystals were collected by filtration and washed with water. Thus 10.9 g (59.4 mmol) of 2-methyl-4-methoxy-5-nitrophenol was obtained. The yield was 100%.
後処理
- additionwas added
- temperatureThe obtained mixture was heated
- temperatureunder reflux for 1 hour
- temperatureAfter cooling
- customcrystals were precipitated
- filtrationThe crystals were collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-3bf7c218666e4c9cb9b7629f55677f43
- 出典データセット
- uspto-grants-1992_04
- 特許番号
- US05104414
反応ノート
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