3-chloro-4-(trifluoromethoxy)benzamide → 3-chloro-4-(trifluoromethoxy)benzonitrile

HRID 1030090ノート

反応式

HRID 1030090 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][C:12]([F:15])([F:14])[F:13])[C:5]([NH2:7])=O>O=S(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][C:12]([F:13])([F:14])[F:15])[C:5]#[N:7]

参加物

3

反応物 1

HCID 27738443-chloro-4-(trifluoromethoxy)benzamide

生成物 1

HCID 27738463-chloro-4-(trifluoromethoxy)benzonitrile収率 85%

試薬・触媒・溶媒 1

HCID 24386Thionyl Chloride溶媒

反応条件

温度
85 °C

実験手順

750 ml of SOCl2 were added to 239.5 g (1 mol) of 3-chloro-4-trifluoromethoxybenzamide and the mixture was heated slowly (corresponding to the evolution of gas) to 85° C. The mixture was then fractionally distilled and 189 g of product having a boiling point at 13 mbar of 96° C. and a melting point of 38° to 40° C. were obtained. This corresponds to a yield of 85% of theory.

後処理

  1. distillationThe mixture was then fractionally distilled
  2. customat 13 mbar of 96° C.
  3. customa melting point of 38° to 40° C. were obtained

出典と根拠

ORDレコード
ord-ad79efa0e84b4743834490f2c901e2eb
出典データセット
uspto-grants-1992_04
特許番号
US05104879

反応ノート

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