Thionyl Chloride → 2-Chloro-4-methylthiazole-5-carboxylic acid chloride
反応式
[Cl:1][C:2]1[S:3][C:4]([C:8]([OH:10])=O)=[C:5]([CH3:7])[N:6]=1.S(Cl)([Cl:13])=O>CN(C)C=O>[Cl:1][C:2]1[S:3][C:4]([C:8]([Cl:13])=[O:10])=[C:5]([CH3:7])[N:6]=1参加物
4
実験手順
8.8 g of 2-chloro-4-methylthiazole-5-carboxylic acid was suspended in 7 ml of thionyl chloride, and one drop of N,N-dimethylformamide was added. The mixture was heated under reflux for 1 hour, and then the excess of thionyl chloride was evaporated under reduced pressure. Benzene (10 ml) was added, and the mixture was evaporated under reduced pressure. This procedure was repeated three times to give 9.7 g of 2-chloro-4-methylthiazole-5-carboxylic acid chloride which was used in the following reaction without purification.
後処理
- temperatureThe mixture was heated
- temperatureunder reflux for 1 hour
- customthe excess of thionyl chloride was evaporated under reduced pressure
- additionBenzene (10 ml) was added
- customthe mixture was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-9526b21a2f9149768b8fd585de14c167
- 出典データセット
- uspto-grants-1992_04
- 特許番号
- US05104886
反応ノート
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