Sodium Hydroxide → 1-Chloro-3-(4-aminophenoxy)propane
反応式
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][CH:7]=1.[OH-].[Na+]>CCO>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=1参加物
4
実験手順
A mixture of 1-chloro-3-(4-nitrophenoxy)propane (830 mg, 3.85 mmol), stannous chloride dihydrate (4.3 g, 19.25 mmol), and EtOH (20 mL) was heated under reflux for 3 hours. The mixture was cooled, 2.5N NaOH (19 mL) was added, and the precipitate was removed by filtration. The filtrate was concentrated to 10 mL and extracted with EtOAc. The extracts were dried (MgSO4) and concentrated to give 700 mg (98%) of product as a brown oil.
後処理
- temperaturewas heated
- temperatureunder reflux for 3 hours
- temperatureThe mixture was cooled
- customthe precipitate was removed by filtration
- concentrationThe filtrate was concentrated to 10 mL
- extractionextracted with EtOAc
- dry with materialThe extracts were dried (MgSO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-a4a9a3e2a9ec4d1cbadba9c6902fe7d1
- 出典データセット
- uspto-grants-1992_04
- 特許番号
- US05104892
反応ノート
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