Sodium Iodide → N-[4-(3-Iodo-1-propyloxy)phenyl]methanesulfonamide

HRID 1030276ノート

反応式

HRID 1030276 の反応式
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])=[CH:8][CH:7]=1.[I-:17].[Na+]>CC(C)=O>[I:17][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 19822347N-[4-(3-Chloro-1-propyloxy)phenyl]methanesulfonamide

生成物 1

HCID 19822359N-[4-(3-Iodo-1-propyloxy)phenyl]methanesulfonamide収率 96.7%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of N-[4-(3-chloro-1-propyloxy)phenyl]methanesulfonamide (1.03 g, 3.90 mmol) and sodium iodide (1.75 g, 11.70 mmol) in acetone (15 mL) was heated under reflux for 18 hours. The mixture was concentrated, taken up in EtOAc, and washed with brine, 10% aqueous sodium bisulfite, and brine. The organic phase was dried (MgSO4) and concentrated to give 1.34 g (96%) of product as an off-white solid m.p. 109°-111° C.

後処理

  1. temperatureunder reflux for 18 hours
  2. concentrationThe mixture was concentrated
  3. washwashed with brine, 10% aqueous sodium bisulfite, and brine
  4. dry with materialThe organic phase was dried (MgSO4)
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-b9c2efe2389f4fba86b97cbb3cda15c3
出典データセット
uspto-grants-1992_04
特許番号
US05104892

反応ノート

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