Sodium Iodide → N-[4-(3-Iodo-1-propylthio)phenyl]methanesulfonamide

HRID 1030281ノート

反応式

HRID 1030281 の反応式
Cl[CH2:2][CH2:3][CH2:4][S:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])=[CH:8][CH:7]=1.[I-:17].[Na+]>CC(C)=O>[I:17][CH2:2][CH2:3][CH2:4][S:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 19822356N-[4-(3-chloro-1-propylthio)phenyl]methanesulfonamide

生成物 1

HCID 19822344N-[4-(3-Iodo-1-propylthio)phenyl]methanesulfonamide収率 92.4%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of N-[4-(3-chloro-1-propylthio)phenyl]methanesulfonamide (4.0 g, 0.014 mol) and sodium iodide (6.4 g 0.043 mol) in acetone (55 mL) was heated under reflux for 18 hours. The mixture was concentrated, taken up in EtOAc, washed with brine, 10% aqueous sodium bisulfite, brine, dried (MgSO4), and concentrated to give 4.8 g (91%) of product as an off-white and solid m.p. 59°-63° C.

後処理

  1. temperatureunder reflux for 18 hours
  2. concentrationThe mixture was concentrated
  3. washwashed with brine, 10% aqueous sodium bisulfite, brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-540777f297874d6fa14279382e7667f3
出典データセット
uspto-grants-1992_04
特許番号
US05104892

反応ノート

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