HCID 3395423、化合物 → 4-(1,3-Thiazol-4-yl)phenol

HRID 1030457ノート

反応式

HRID 1030457 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[CH:17][S:18][CH:19]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>Br>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:16]=[CH:17][S:18][CH:19]=2)=[CH:13][CH:14]=1

参加物

3

反応物 1

HCID 3395423HCID 3395423、化合物

生成物 1

HCID 98153854-(1,3-Thiazol-4-yl)phenol収率 63.9%

試薬・触媒・溶媒 1

HCID 260Hydrogen Bromide溶媒

反応条件

温度
100 °C

実験手順

To 4-(4-benzyloxyphenyl)thiazole (1.1 g) was added 47% aqueous hydrogen bromide (10ml), and the mixture was stirred at 100° C. for 30 minutes. Ice-water was added to the reaction mixture and extracted with ethyl acetate. The ethyl acetate layer was washed with saturated saline, dried by anhydrous sodium sulfate and then concentrated. Crystals were collected by filtration by using hexane to give 4-(4-hydroxyphenyl) thiazole (466 mg, 63.8%). The crystals were purified by recrystallization from methylene chloride-hexane. m.p. 161.5°-162° C.

後処理

  1. extractionextracted with ethyl acetate
  2. washThe ethyl acetate layer was washed with saturated saline
  3. dry with materialdried by anhydrous sodium sulfate
  4. concentrationconcentrated
  5. filtrationCrystals were collected by filtration

出典と根拠

ORDレコード
ord-202b7cb0ac41461ab7c4dd90063c88b6
出典データセット
uspto-grants-1992_04
特許番号
US05106732

反応ノート

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