Hydrochloric Acid → 4-Phenylmethyl-2,3-thiomorpholinedione-2-oxime

HRID 1030472ノート

反応式

HRID 1030472 の反応式
[C:1]1([CH2:7][N:8]2[CH2:12][CH2:11][S:10][C:9]2=[CH:13][N+:14]([O-:16])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].C([OH:21])C.Cl>O>[C:1]1([CH2:7][N:8]2[CH2:12][CH2:11][S:10][C:13](=[N:14][OH:16])[C:9]2=[O:21])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 30243963-Benzyl-2-nitromethylene-thiazolidine

生成物 1

HCID 851863704-Phenylmethyl-2,3-thiomorpholinedione-2-oxime

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2.36 g (0.01 mol) of 3-phenylmethyl-2-nitromethylenethiazolidine are boiled under reflux in the mixture of 50 ml of 1N sodium hydroxide solution and 25 ml of ethanol until the dissolution of the starting substance (when, based on the TLC examination, no starting substance is detected in a sample taken from the reaction mixture). Then, the mixture is cooled, acidified by adding hydrochloric acid diluted to 1:1 with water (to a pH value of 1), the precipitated product is filtered off, washed with water and dried to give the title compound in a yield of 2,15 g (91%), m.p.: 225°-227° C.

後処理

  1. temperatureThen, the mixture is cooled
  2. filtrationis filtered off
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-31ba42b11ab441dfbe9a2c3b3d10d5b8
出典データセット
uspto-grants-1992_04
特許番号
US05106846

反応ノート

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