1-[3-[4-(4,5-Dihydro-2-oxazolyl)phenoxy]propyl]-4-(phenylmethyl)piperazine → 1-[3-[4-(4,5-Dihydro-2-oxazolyl)phenoxy]propyl]piperazine

HRID 1030889ノート

反応式

HRID 1030889 の反応式
[O:1]1[CH2:5][CH2:4][N:3]=[C:2]1[C:6]1[CH:28]=[CH:27][C:9]([O:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][N:17](CC3C=CC=CC=3)[CH2:16][CH2:15]2)=[CH:8][CH:7]=1.[H][H]>[Pd].CO>[O:1]1[CH2:5][CH2:4][N:3]=[C:2]1[C:6]1[CH:7]=[CH:8][C:9]([O:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)=[CH:27][CH:28]=1

参加物

5

反応物 2

HCID 149891781-[3-[4-(4,5-Dihydro-2-oxazolyl)phenoxy]propyl]-4-(phenylmethyl)piperazineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 149891791-[3-[4-(4,5-Dihydro-2-oxazolyl)phenoxy]propyl]piperazine収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 56 parts of 1-[3-[4-(4,5-dihydro-2-oxazolyl)phenoxy]propyl]-4-(phenylmethyl)piperazine and 480 parts of methanol was hydrogenated at normal pressure and at 50° C. with 5 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was taken up in water and the product was extracted with dichloromethane. The extract was dried, filtered and evaporated, yielding 46.9 parts (100%) of 1-[3-[4-(4,5-dihydro-2-oxazolyl)phenoxy]propyl]piperazine as a residue (int. 16).

後処理

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated
  3. extractionthe product was extracted with dichloromethane
  4. customThe extract was dried
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-0e334ab19390416dade52cd7cd51d43e
出典データセット
uspto-grants-1992_04
特許番号
US05106973

反応ノート

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