Nitric Acid → 7-Fluoro-6-nitro-2H-1,4-benzoxazin-3(4H)-one

HRID 1030960ノート

反応式

HRID 1030960 の反応式
[F:1][C:2]1[CH:12]=[CH:11][C:5]2[NH:6][C:7](=[O:10])[CH2:8][O:9][C:4]=2[CH:3]=1.[N+:13]([O-])([OH:15])=[O:14]>S(=O)(=O)(O)O>[F:1][C:2]1[C:12]([N+:13]([O-:15])=[O:14])=[CH:11][C:5]2[NH:6][C:7](=[O:10])[CH2:8][O:9][C:4]=2[CH:3]=1

参加物

4

反応物 2

HCID 944Nitric AcidHCID 137312957-fluoro-3,4-dihydro-2H-1,4-benzoxazin-3-one

生成物 1

HCID 137312977-Fluoro-6-nitro-2H-1,4-benzoxazin-3(4H)-one

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

A solution of 7-fluoro-3,4-dihydro-3-oxo-2H-1,4-benzoxazine (2.0 gram) in 80% aqueous sulfuric acid (30 ml) is cooled to 0° to 5° C., and 60% nitric acid (1.6 g) is gradually added thereto at 0° to 5° C. The resultant mixture is stirred at the same temperature for 30 minutes and poured onto ice water. The precipitated crystals are collected by filtration, washed with water and dried to give 7-fluoro-3,4-dihydro-3-oxo-6-nitro-2H-1,4-benzoxazine.

後処理

  1. customat 0° to 5° C
  2. additionpoured onto ice water
  3. filtrationThe precipitated crystals are collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-d029f7f79e154f1d93f45f391aeb1880
出典データセット
uspto-grants-1992_04
特許番号
US05108488

反応ノート

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