6-(4-amino-3-nitrophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one → 6-(3,4-Diaminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][C:3]=1[N+:16]([O-])=O>CO.[Pd]>[NH2:16][C:3]1[CH:4]=[C:5]([C:8]2[CH:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)[CH:6]=[CH:7][C:2]=1[NH2:1]参加物
4
実験手順
100 g of 6-(4-amino-3-nitrophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one are dissolved in 2 1 of methanol and hydrogenated over 20 g of 5% palladium-on-charcoal at 20° and 1 bar until absorption ceases. Filtration and evaporation give 6-(3,4-diaminophenyl)-5-methyl-2,3,4,5-tetrahydropyridazin-3-one, m.p. 195°-196°.
後処理
- custom1 bar until absorption ceases
- filtrationFiltration and evaporation
出典と根拠
- ORDレコード
- ord-7a014fcbbac240ef9286aadd684ca0cc
- 出典データセット
- uspto-grants-1990_09
- 特許番号
- US04954499
反応ノート
読み込み中…