2-(4-(Trifluoromethyl)phenyl)acetyl chloride → HCID 67869678、化合物

HRID 1031615ノート

反応式

HRID 1031615 の反応式
[N:1]1([CH2:6][CH:7]2[C:16]3[C:11](=[C:12]([O:17][CH3:18])[CH:13]=[CH:14][CH:15]=3)[CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:19][C:20]([F:32])([F:31])[C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]([Cl:30])=[O:29])=[CH:23][CH:22]=1>C(Cl)(Cl)Cl>[ClH:30].[N:1]1([CH2:6][C:7]2([C:28](=[O:29])[CH2:27][C:24]3[CH:23]=[CH:22][C:21]([C:20]([F:31])([F:19])[F:32])=[CH:26][CH:25]=3)[C:16]3[C:11](=[C:12]([O:17][CH3:18])[CH:13]=[CH:14][CH:15]=3)[CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 148109432-(4-(Trifluoromethyl)phenyl)acetyl chlorideHCID 15005443HCID 15005443、化合物

生成物 1

HCID 67869678HCID 67869678、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

750 mg (3.05 mmoles) of 1-(pyrrolidin-1-yl)methyl-5-methoxy1,2,3,4-tetrahydroisoquinoline were dissolved in 10 ml of dry chloroform. 810 mg (3.64 mmoles) of 4-trifluoromethylphenyl acetyl chloride, dissolved in 10 ml of chloroform, were added dropwise to the solution at 0° C. The reaction mixture was allowed to reach room temperature and left overnight.

後処理

  1. additionwere added dropwise to the solution at 0° C
  2. customto reach room temperature

出典と根拠

ORDレコード
ord-01a2b100850643bdaf46a81f8d388d3a
出典データセット
uspto-grants-1990_09
特許番号
US04954509

反応ノート

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