Thionyl Chloride → HCID 22166995、化合物
反応式
S(Cl)([Cl:3])=O.O[CH2:6][C:7]1[CH:12]=[C:11]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[N:10]=[CH:9][N:8]=1>ClCCl>[ClH:3].[Cl:3][CH2:6][C:7]1[CH:12]=[C:11]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[N:10]=[CH:9][N:8]=1参加物
4
実験手順
A solution of 36 ml of thionyl chloride in 30 ml of dichloromethane was added dropwise, at 0° C., to a solution of 3 g of 4-hydroxymethyl-6-morpholinopyrimidine in 30 ml of dichloromethane. The reaction solution was allowed to reach room temperature and was concentrated in vacuo. Addition of diethyl ether resulted in precipitation of 3.2 g of 4-chloromethyl-6-morpholinopyrimidine hydrochloride (melting point 139° C. [decomposition]).
後処理
- customto reach room temperature
- concentrationwas concentrated in vacuo
- additionAddition of diethyl ether
出典と根拠
- ORDレコード
- ord-cfef2a657bdd44bc8f1b503de7ac7c63
- 出典データセット
- uspto-grants-1990_09
- 特許番号
- US04956366
反応ノート
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