Methanol → Anecortave

HRID 1032030

反応式

HRID 1032030 の反応式
C([O:4][CH2:5][C:6](=[O:28])[C@:7]1([OH:27])[C@:24]2([CH3:25])[C@H:10]([C@H:11]3[C:21](=[CH:22][CH2:23]2)[C@:19]2([CH3:20])[C:14](=[CH:15][C:16](=[O:26])[CH2:17][CH2:18]2)[CH2:13][CH2:12]3)[CH2:9][CH2:8]1)(=O)C.CO>C(Cl)Cl>[OH:27][C@:7]1([C@:24]2([CH3:25])[C@H:10]([C@H:11]3[C:21](=[CH:22][CH2:23]2)[C@:19]2([CH3:20])[C:14](=[CH:15][C:16](=[O:26])[CH2:17][CH2:18]2)[CH2:13][CH2:12]3)[CH2:9][CH2:8]1)[C:6](=[O:28])[CH2:5][OH:4]

参加物

4

反応物 2

HCID 887MethanolHCID 111332Anecortave Acetate

生成物 1

HCID 7074810Anecortave収率 89.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

At room temperature, 1.5 g of 21-acetoxy-17-hydroxy-4,9(11)-pregnadiene-3,20-dione in 40 ml is agitated for 2 hours at room temperature with 15 ml of methanol 0.2N methanolic potassium hydroxide solution. The reaction mixture is introduced into ice water. The precipitated product is suctioned off, dissolved in methylene chloride, washed with water, and dried over sodium sulfate, thus obtaining 1.2 g of 17,21-dihydroxy-4,9(11) pregnadiene3,20-dione; mp 248.2° C.

後処理

  1. washwashed with water
  2. dry with materialdried over sodium sulfate

出典と根拠

ORDレコード
ord-55c8034840ae47a2b610f62f85552da4
出典データセット
uspto-grants-1990_09
特許番号
US04956482

関連ノート

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