Oxalyl chloride → 2,3-Dihydro-6-methoxy-1H-indene-1-carbonyl chloride
反応式
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][CH:9]2[C:12]([OH:14])=O)=[CH:5][CH:4]=1.C(Cl)(=O)C([Cl:18])=O>C(Cl)Cl.CN(C=O)C>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][CH:9]2[C:12]([Cl:18])=[O:14])=[CH:5][CH:4]=1参加物
5
実験手順
6-Methoxy-indane-1-carboxylic acid, 6.0 g (31 mmol), a compound of Formula 3, was dissolved in 50 ml of methylene chloride and reacted at ambient temperature with 4.0 ml (46 mmol) of oxalyl chloride in the presence of one drop of DMF. After 2 hours, the reaction mixture was brought to reflux and maintained for 15 minutes. It was then concentrated under vacuum and stirred for about 30 minutes, yielding 6-methoxy-indane-1-carboxylic acid chloride, which was sufficiently pure to be used for the next step.
後処理
- temperatureto reflux
- temperaturemaintained for 15 minutes
- concentrationIt was then concentrated under vacuum
出典と根拠
- ORDレコード
- ord-1dd86bb3526441e782fc016bbe0fa7f7
- 出典データセット
- uspto-grants-1990_09
- 特許番号
- US04957914
反応ノート
読み込み中…