Ammonia → HCID 19759073、化合物

反応式

C[O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([C:12]2[N:17]=[CH:16][CH:15]=[CH:14][N:13]=2)(=[O:11])=[O:10])=[CH:5][CH:4]=1.Br.N>>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([C:12]2[N:13]=[CH:14][CH:15]=[CH:16][N:17]=2)(=[O:11])=[O:10])=[CH:5][CH:4]=1

参加物

反応物 3

HCID 222Ammonia

HCID 260Hydrogen Bromide

HCID 197590592-(4-Methoxybenzene-1-sulfonyl)pyrimidine

生成物 1

HCID 19759073HCID 19759073、化合物

反応条件

温度: 90 °C

実験手順

A mixture of 4.6×10-3 mol of 2-(4-methoxybenzenesulphonyl)pyrimidine and 10 of 47%-hydrobromic acid was heated for - hour at 90° C. The reaction medium was neutralized to a pH of 7 with an ammonia solution and the pasty residue was extracted with dichloromethane. The organic phase was then dried and evaporated and the residue so provided was purified by chromatography on a silica column using dichloromethane as eluent.