Triethylamine → N-[2-benzyloxy-4-(2-dipropylaminoethyl)phenyl]butyramide

HRID 1032539ノート

反応式

HRID 1032539 の反応式
C(N(CC)CC)C.[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][N:17]([CH2:21][CH2:22][CH3:23])[CH2:18][CH2:19][CH3:20])=[CH:11][C:10]=1[O:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[C:32](Cl)(=[O:36])[CH2:33][CH2:34][CH3:35]>O1CCCC1.O>[CH2:25]([O:24][C:10]1[CH:11]=[C:12]([CH2:15][CH2:16][N:17]([CH2:18][CH2:19][CH3:20])[CH2:21][CH2:22][CH3:23])[CH:13]=[CH:14][C:9]=1[NH:8][C:32](=[O:36])[CH2:33][CH2:34][CH3:35])[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

参加物

6

反応物 3

HCID 8471TriethylamineHCID 8855Butyryl chlorideHCID 22165977HCID 22165977、化合物

生成物 1

HCID 22166027N-[2-benzyloxy-4-(2-dipropylaminoethyl)phenyl]butyramide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

0.3 ml of triethylamine is added to 0.65 g of N-[2-(4-amino-3-benzyloxyphenyl)ethyl]-N,N-dipropylamine in 10 ml of tetrahydrofuran, and then 0.23 ml of butyryl chloride is added dropwise thereto. The reaction mixture is stirred for one hour at room temperature, diluted with water, and the product extracted by shaking with methylene chloride, isolating 770 mg of N-[2-benzyloxy-4-(2-dipropylaminoethyl)phenyl]butyramide as an oil from the methylene chloride solution.

後処理

  1. extractionthe product extracted
  2. stirringby shaking with methylene chloride

出典と根拠

ORDレコード
ord-4356bc771a284de6a5842a169bffc404
出典データセット
uspto-grants-1990_09
特許番号
US04958026

反応ノート

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