p-Toluenesulfonic acid → HCID 178475878、化合物

反応式

[OH:1][C:2]1[N:7]2[N:8]=[C:9]([CH3:11])[N:10]=[C:6]2[N:5]=[C:4]([CH2:12][OH:13])[CH:3]=1.CN([CH:17]=[O:18])C.[C:19]1(C)C=CC(S(O)(=O)=O)=CC=1>C(O)(=O)C>[C:17]([O:13][CH2:12][C:4]1[CH:3]=[C:2]([OH:1])[N:7]2[N:8]=[C:9]([CH3:11])[N:10]=[C:6]2[N:5]=1)(=[O:18])[CH3:19]

参加物

反応条件

温度: 50 °C

実験手順

A mixture of 33.06 g of 7-hydroxy-5-hydroxymethyl-2-methyl- s-triazolo[1,5-a]pyrimidine, 500 ml of DMF, 86 ml of anhydrous acetic acid and 1.5 g of p-toluenesulfonic acid was stirred in a bath at 50 ° C for 6 hours. To an oily residue obtained by removing DMF was added 300 ml of isopropanol to dissolve therein, and the solution was added dropwise in 4 liters of ether. Precipitates were collected by filtration and dried to obtain 38.08 g of the title compound.