Methanesulfonyl chloride → Dofetilide

HRID 1032671

反応式

HRID 1032671 の反応式
O.Cl.Cl.[NH2:4][C:5]1[CH:28]=[CH:27][C:8]([O:9][CH2:10][CH2:11][N:12]([CH3:26])[CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([NH:21][S:22]([CH3:25])(=[O:24])=[O:23])=[CH:17][CH:16]=2)=[CH:7][CH:6]=1.NC1C=CC(OCCN(CCC2C=CC(N[S:48]([CH3:51])(=[O:50])=[O:49])=CC=2)C)=CC=1.Cl.Cl.S(Cl)(C)(=O)=O>N1C=CC=CC=1>[CH3:51][S:48]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH2:10][CH2:11][N:12]([CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([NH:21][S:22]([CH3:25])(=[O:24])=[O:23])=[CH:17][CH:16]=2)[CH3:26])=[CH:27][CH:28]=1)(=[O:50])=[O:49]

参加物

4

反応物 2

HCID 31297Methanesulfonyl chlorideHCID 678955481-(4-aminophenoxy)-2-[N-methyl-N-(4-methanesulphonamidophenethyl)amino]ethane dihydrochloride hemihydrate

生成物 1

HCID 71329Dofetilide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

The title compound was prepared by mesylation of 1-(4-aminophenoxy)-2-[N-methyl-N-(4-methanesulphonamidophenethyl)amino]ethane dihydrochloride hemihydrate (95 mg) with mesyl chloride ir pyridine according to the procedure of Example 19(C), yield 30 mg, m.p. 147°-149°, confirmed spectroscopically to be identical to the product of Example 7(C).

出典と根拠

ORDレコード
ord-51d1dc568a6941d8a219809d22058174
出典データセット
uspto-grants-1990_09
特許番号
US04959366

関連ノート

読み込み中…