HCID 15057055、化合物 → 4-Phenoxypyridin-3-amine
反応式
[N+:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([O-])=O>C(O)C.[Pd]>[O:10]([C:9]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[NH2:1])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1参加物
4
実験手順
To a slurry of 10% Pd/C in 5 ml of absolute ethanol was added 3-nitro-4-phenoxypyridine (7.5 g) in 245 ml of ethanol. This mixture was shaken on a Parr apparatus for two hours. The mixture was filtered and the filtrate concentrated to yield an oil (6.4 g) which was eluted with ethyl acetate on a silica gel column in HPLC. The desired fractions were concentrated to yield an oil (4.5 g). This material was distilled using a Kugelrohr apparatus to yield an oil (1.8 g).
後処理
- filtrationThe mixture was filtered
- concentrationthe filtrate concentrated
出典と根拠
- ORDレコード
- ord-8ad0e2267f7148c082922b22703cc09f
- 出典データセット
- uspto-grants-1990_09
- 特許番号
- US04959377
反応ノート
読み込み中…