Dichloromethane → 1-Methoxy-4-methyl-2-nitrobenzene

HRID 1032960

反応式

HRID 1032960 の反応式
[N+:1]([C:4]1[C:9]([OH:10])=[CH:8][CH:7]=[C:6]([CH3:11])[CH:5]=1)([O-:3])=[O:2].[CH2:12](Cl)Cl.[OH-].[Na+].S(OC)(OC)(=O)=O>S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.O>[CH3:11][C:6]1[CH:7]=[CH:8][C:9]([O:10][CH3:12])=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1

参加物

7

反応物 4

HCID 6344DichloromethaneHCID 6497Dimethyl SulfateHCID 83914-Methyl-2-nitrophenolHCID 14798Sodium Hydroxide

生成物 1

HCID 670581-Methoxy-4-methyl-2-nitrobenzene

試薬・触媒・溶媒 2

HCID 94433Tetrabutylammonium hydrogen sulfate触媒HCID 962Water溶媒

実験手順

A reaction mixture of 2-nitro-p-cresol (23.58 g, 0.154 mmol), methylene chloride (200 ml), tetra-n-butylammonium hydrogensulfate (5.15 g, 15.2 mmol), 1N sodium hydroxide (170 ml) and dimethyl sulfate (16.0 ml, 0.169 mmol) was stirred at room temperature for 2 hours. The reaction mixture was poured into water and extracted with methylene chloride. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and evaporated. The concentrate was immediately used for the next reaction.

後処理

  1. extractionextracted with methylene chloride
  2. washThe organic layer was washed with brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customevaporated
  5. customThe concentrate was immediately used for the next reaction

出典と根拠

ORDレコード
ord-094d3f7d7ae542c3b24245f12e026bc1
出典データセット
uspto-grants-1994_05
特許番号
US05308840

関連ノート

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