2-Methoxy-3-cyano-5-ethyl-6-methylpyridine → 2-Methoxy-3-(aminomethyl)-5-ethyl-6-methylpyridine

HRID 1033010ノート

反応式

HRID 1033010 の反応式
[CH3:1][O:2][C:3]1[C:8]([C:9]#[N:10])=[CH:7][C:6]([CH2:11][CH3:12])=[C:5]([CH3:13])[N:4]=1>CO.Cl.[Pd]>[CH3:1][O:2][C:3]1[C:8]([CH2:9][NH2:10])=[CH:7][C:6]([CH2:11][CH3:12])=[C:5]([CH3:13])[N:4]=1

参加物

5

反応物 1

HCID 104422282-Methoxy-3-cyano-5-ethyl-6-methylpyridine

生成物 1

HCID 103299382-Methoxy-3-(aminomethyl)-5-ethyl-6-methylpyridine収率 89.1%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

実験手順

A solution of 2-methoxy-3-cyano-5-ethyl-6-methylpyridine (344 mg, 1.95 mmol) in methanol (8 mL) and 4.9M methanolic HCl (5 mL) containing 5% palladium on carbon (100 mg) was hydrogenated at atmospheric pressure for 10-20 hours. The catalyst was filtered off and the solvent evaporated. This residue was made basic with sodium hydroxide and the product was extracted into methylene chloride, dried (Na2SO4), filtered and evaporated to give 313 mg (89% yield) of oily product.

後処理

  1. filtrationThe catalyst was filtered off
  2. customthe solvent evaporated
  3. extractionthe product was extracted into methylene chloride
  4. dry with materialdried (Na2SO4)
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-6a900438c31649d6a09702299752c5b5
出典データセット
uspto-grants-1994_05
特許番号
US05308854

反応ノート

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