Thiophosgene → HCID 21487065、化合物

HRID 1033199ノート

反応式

HRID 1033199 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:11][CH3:12])[CH2:9][CH3:10])=[N:6][CH:7]=1.[C:13](Cl)(Cl)=[S:14].C(=O)([O-])[O-].[K+].[K+]>O.C(Cl)(Cl)Cl>[CH2:9]([N:8]([CH2:11][CH3:12])[C:5]1[CH:4]=[CH:3][C:2]([N:1]=[C:13]=[S:14])=[CH:7][N:6]=1)[CH3:10]

参加物

6

反応物 3

HCID 10040ThiophosgeneHCID 11430Potassium CarbonateHCID 117884862-N,2-N-diethylpyridine-2,5-diamine

生成物 1

HCID 21487065HCID 21487065、化合物収率 19.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6212Chloroform溶媒

実験手順

Using procedures similar to those employed in Step A of Example 8, the reaction of i5.9 g (0.096 mole of 5-amino-2-diethylaminopyridine with 22.2 g (0.193 mole) of thiophosgene and 5.0 g (0.036 mole) of potassium carbonate in 50 ml of water and 150 ml of chloroform yielded 3.8 g of (2-diethylaminopyridin-5-yl) isothiocyanate as a solid. The nmr spectrum was consistent with the proposed structure.

出典と根拠

ORDレコード
ord-7483503acfaa418a8d926c988b1cf750
出典データセット
uspto-grants-1994_05
特許番号
US05310724

反応ノート

読み込み中…