4-Hydroxybenzoic Acid → Ethylene glycol MONO-4-hydroxybenzoate

HRID 1033284ノート

反応式

HRID 1033284 の反応式
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[CH2:11]1[O:13][CH2:12]1>C(O)(C)C>[OH:13][CH2:12][CH2:11][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([OH:1])=[CH:3][CH:4]=1

参加物

4

反応物 2

HCID 1354-Hydroxybenzoic AcidHCID 6354Ethylene Oxide

生成物 1

HCID 267950Ethylene glycol MONO-4-hydroxybenzoate

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

Into an autoclave, 138 parts by weight of p-hydroxybenzoic acid, 1 part by weight of Na2CO2 and 300 parts by weight of isopropanol were charged, and at 90° C., 66 parts by weight of ethylene oxide was added thereto, and the reaction was conducted. After the reaction, the mixture was cooled, and the precipitate was collected by filtration and recrystallized twice from water to obtain 55 parts by weight of p-hydroxylbenzoic acid-β-hydroxyethyl ester ##STR88## having a melting point of 141° C. The structure was confirmed by 1H-NMR.

後処理

  1. customAfter the reaction
  2. temperaturethe mixture was cooled
  3. filtrationthe precipitate was collected by filtration
  4. customrecrystallized twice from water

出典と根拠

ORDレコード
ord-06662c88b742439d822a83102e60ca05
出典データセット
uspto-grants-1994_05
特許番号
US05310859

反応ノート

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