HCID 15341804、化合物 → HCID 15341825、化合物

HRID 1033645ノート

反応式

HRID 1033645 の反応式
[OH:1][C:2]1[C:14]([CH2:15][CH:16]=[CH2:17])=[C:13]([OH:18])[CH:12]=[CH:11][C:3]=1[C:4]([N:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5]>C(O)C.[Pd]>[OH:1][C:2]1[C:14]([CH2:15][CH2:16][CH3:17])=[C:13]([OH:18])[CH:12]=[CH:11][C:3]=1[C:4]([N:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:5]

参加物

4

反応物 1

HCID 15341804HCID 15341804、化合物

生成物 1

HCID 15341825HCID 15341825、化合物収率 86%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

1-[2,4-dihydroxy-3-(2-propenyl)benzoyl]pyrrolidine (750 mg) in 2 ml ethanol was hydrogenated at room temperature and 5 psi for three hours using 4% Pd/C as catalyst. The solvent was removed under vacuum and the residue was chromatographed on silica gel using 50/50 ethyl acetate/hexane as eluant to give the product (650 mg).

後処理

  1. customwas hydrogenated at room temperature
  2. customThe solvent was removed under vacuum
  3. customthe residue was chromatographed on silica gel using 50/50 ethyl acetate/hexane as eluant

出典と根拠

ORDレコード
ord-ca9468b92a374f6a99fc3bb346ab8b1a
出典データセット
uspto-grants-1994_05
特許番号
US05310951

反応ノート

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