Hydrochloric Acid → 3-Chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester

HRID 1033702

反応式

HRID 1033702 の反応式
CC1C=CC(S(N(Cl)[Cl:12])(=O)=O)=CC=1.Cl.[CH3:15][CH:16]([CH2:28][CH3:29])[CH2:17][O:18][C:19](=[O:27])[C:20]1[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=1>C(O)(=O)C>[CH3:15][CH:16]([CH2:28][CH3:29])[CH2:17][O:18][C:19](=[O:27])[C:20]1[CH:21]=[CH:22][C:23]([OH:26])=[C:24]([Cl:12])[CH:25]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 68056Dichloramine-THCID 13530949Benzoic acid, 4-hydroxy-, 2-methylbutyl ester

生成物 1

HCID 230416823-Chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester収率 144.2%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

On the other hand, dichloramine T (28.0 g, 0.12 mol) was dissolved in acetic acid (450 ml), and hydrochloric acid (1.5 ml) was added. The resulting solution was dropwise added to a solution of the above p-hydroxybenzoic acid 2-methyl-butyl ester (50 g, 0.24 mol) dissolved in acetic acid (450 ml), followed by refluxing the mixture, allowing to stand overnight, distilling off acetic acid and filtering off deposited crystals to obtain 3-chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester (42 g) (b.p. 135°~138° C./4 mmHg).

後処理

  1. temperatureby refluxing the mixture
  2. distillationdistilling off acetic acid
  3. filtrationfiltering off

出典と根拠

ORDレコード
ord-9628d6e533e344f2897cf7d0226e1cb9
出典データセット
uspto-grants-1994_05
特許番号
US05312564

関連ノート

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