Ethyl 4-(hydroxyimino)-5-oxo-1-phenyl-3-pyrrolidineacetate → Ethyl 4-amino-5-oxo-1-phenyl-3-pyrrolidineacetate

反応式

O[N:2]=[C:3]1[C:7](=[O:8])[N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:5][CH:4]1[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17]>CCO.[Pd]>[NH2:2][CH:3]1[C:7](=[O:8])[N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:5][CH:4]1[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17]

参加物

実験手順

A solution of the product of example 63 in EtOH is hydrogenated with 10% palladium on carbon at 60 psi at 60° C. Filtration and purification of the product on silica gel affords the title compound.

後処理

filtrationFiltration and purification of the product on silica gel

出典と根拠

ORDレコード: ord-f6428ceea59541f69d5d9979113c4bc9
出典データセット: uspto-grants-1994_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05314886

反応ノート

読み込み中…

参加物

反応物 1

HCID 86746704Ethyl 4-(hydroxyimino)-5-oxo-1-phenyl-3-pyrrolidineacetate

生成物 1

HCID 53812745Ethyl 4-amino-5-oxo-1-phenyl-3-pyrrolidineacetate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒

HCID 702Ethanol溶媒

実験手順

A solution of the product of example 63 in EtOH is hydrogenated with 10% palladium on carbon at 60 psi at 60° C. Filtration and purification of the product on silica gel affords the title compound.

後処理

filtrationFiltration and purification of the product on silica gel

出典と根拠

ORDレコード: ord-f6428ceea59541f69d5d9979113c4bc9
出典データセット: uspto-grants-1994_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05314886

反応ノート

読み込み中…