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Ethyl p-toluate → 4-(bromomethyl)-N-cyclohexyl-N-methylbenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl p-toluate | HCID 66743 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | N-Cyclohexyl-N,4-dimethylbenzenesulfonamide | HCID 614169 | — |
| 生成物 | 4-(bromomethyl)-N-cyclohexyl-N-methylbenzenesulfonamide | HCID 19023272 | 90.1% |
反応手順
Utilising the procedure described in Example 1(a) employing N-cyclohexyl-N-methyl 4-methylbenzenesulphonamide (20.0 g, 0.075 mol) in lieu of ethyl 4-methylbenzoate and two equivalents of NBS (27.0 g, 0.15 mol) yielded a crude product of N-cyclohexyl-N-methyl 4-bromomethylbenzenesulphonamide (23.4 g, 90%) as an orange oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05314880 |
| 出典データセット | uspto-grants-1994_05 |
| ORD ID | ord-bdb763b948854923a02d346864ef977a |
| 出典メモ | uspto-grants-1994_05 |