Sodium Hydroxide → 6-Chloropyridine-2,3-diamine
反応式
[Sn](Cl)Cl.[Cl:4][C:5]1[N:10]=[C:9]([N+:11]([O-])=O)[C:8]([NH2:14])=[CH:7][CH:6]=1.[OH-].[Na+]>Cl>[Cl:4][C:5]1[N:10]=[C:9]([NH2:11])[C:8]([NH2:14])=[CH:7][CH:6]=1参加物
5
実験手順
A solution of tin (II) chloride (21.8 g) in concentrated hydrochloric acid (30 ml) was added, with cooling, to 6-chloro-3-amino-2-nitropyridine (5 g) and the suspension stirred for 3 hours at room temperature. The pH was adjusted to pH12 (40% NaOH) and the solvent removed in vacuo. The residue was purified by flash column chromatography, eluting with System C (100:8:1), to afford the title compound as a yellow solid (3.29 g).
後処理
- customthe solvent removed in vacuo
- customThe residue was purified by flash column chromatography
- washeluting with System C (100:8:1)
出典と根拠
- ORDレコード
- ord-cd53c226bebf4e1c924f09eb8582b479
- 出典データセット
- uspto-grants-1994_05
- 特許番号
- US05317023
反応ノート
読み込み中…