Thionyl Chloride → 3-tert-Butyldimethylsilyloxybenzoyl chloride

HRID 1034589ノート

反応式

HRID 1034589 の反応式
[Si:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12](O)=[O:13])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].S(Cl)([Cl:20])=O>>[Si:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([Cl:20])=[O:13])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 183695873-{[tert-Butyl(dimethyl)silyl]oxy}benzoic acid

生成物 1

HCID 124484873-tert-Butyldimethylsilyloxybenzoyl chloride

実験手順

Into a 100 mL round bottom flask a mixture of 5 parts of 3-tert-butyldimethylsilyloxybenzoic acid and 25 mL of thionyl chloride was heated at reflux for 90 mins. The reaction mixture was concentrated under reduced pressure to give an oil, yield 5.77 parts of the following structure.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 90 mins
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customto give an oil
  5. customyield 5.77 parts of the following structure

出典と根拠

ORDレコード
ord-83a2bddd1edd472f94e794c5a6a34303
出典データセット
uspto-grants-2013_10
特許番号
US08546150B2

反応ノート

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