[1-(5-Benzyl-5-azaspiro[2.4]hept-7-yl)ethyl]carbamic acid tert-butyl ester → [1-(5-Azaspiro[2.4]hept-7-yl)ethyl]carbamic acid tert-butyl ester

HRID 10346ノート

反応式

HRID 10346 の反応式
[C:1]([O:5][C:6](=[O:24])[NH:7][CH:8]([CH:10]1[C:14]2([CH2:16][CH2:15]2)[CH2:13][N:12](CC2C=CC=CC=2)[CH2:11]1)[CH3:9])([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[C:1]([O:5][C:6](=[O:24])[NH:7][CH:8]([CH:10]1[C:14]2([CH2:15][CH2:16]2)[CH2:13][NH:12][CH2:11]1)[CH3:9])([CH3:2])([CH3:3])[CH3:4]

参加物

5

反応物 2

HCID 21041206[1-(5-Benzyl-5-azaspiro[2.4]hept-7-yl)ethyl]carbamic acid tert-butyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 21041207[1-(5-Azaspiro[2.4]hept-7-yl)ethyl]carbamic acid tert-butyl ester

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of [1-(5-benzyl-5-azaspiro[2.4]hept-7-yl)ethyl]carbamic acid tert-butyl ester (Example A4a, 1.47 g) in methanol (30 mL) in a Parr shaker is treated with 10% palladium on carbon (0.5 g) and hydrogen introduced (50 psi) for 24 hours. The reaction mixture is filtered through celite, washed with methanol, and the combined filtrate concentrated in vacuo to afford the title compound. MS CI: m/z 241 (MH+).

後処理

  1. additionintroduced (50 psi) for 24 hours
  2. filtrationThe reaction mixture is filtered through celite
  3. washwashed with methanol
  4. concentrationthe combined filtrate concentrated in vacuo

出典と根拠

ORDレコード
ord-c97a1145efa84e81865b68656041089c
出典データセット
uspto-grants-2006_08
特許番号
US07094780B1

反応ノート

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