Tert-butyl trans-1-benzyl-4-cyclopropylpiperidin-3-ylcarbamate → Tert-butyl-trans-4-cyclopropylpiperidin-3-ylcarbamate

HRID 1034651ノート

反応式

HRID 1034651 の反応式
C([N:8]1[CH2:13][CH2:12][C@@H:11]([CH:14]2[CH2:16][CH2:15]2)[C@H:10]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[C:20]([O:19][C:18](=[O:24])[NH:17][C@H:10]1[C@H:11]([CH:14]2[CH2:15][CH2:16]2)[CH2:12][CH2:13][NH:8][CH2:9]1)([CH3:23])([CH3:21])[CH3:22]

参加物

5

反応物 2

HCID 67045345Tert-butyl trans-1-benzyl-4-cyclopropylpiperidin-3-ylcarbamateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 86652140Tert-butyl-trans-4-cyclopropylpiperidin-3-ylcarbamate収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of tert-butyl trans-1-benzyl-4-cyclopropylpiperidin-3-ylcarbamate (1.20 g, 3.63 mmol) and 10% Pd/C (0.39 g, 0.36 mmol) in methanol (20 mL) was charged with 1 atmosphere hydrogen and stirred at room temperature for 18 hours. The catalyst was removed by filtration and washed with methanol (20 mL). The filtrate was concentrated in vacuo to give tert-butyl-trans-4-cyclopropylpiperidin-3-ylcarbamate (0.87 g, 100%) as a solid.

後処理

  1. customThe catalyst was removed by filtration
  2. washwashed with methanol (20 mL)
  3. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-42300988fe8e45d783a9e5ae5f1c3ff5
出典データセット
uspto-grants-2013_10
特許番号
US08545897B2

反応ノート

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