Nitric Acid → 5-ethoxy-4-fluoro-3-nitro-1H-pyrrolo[2,3-b]pyridine

反応式

[CH2:1]([O:3][C:4]1[C:5]([F:13])=[C:6]2[CH:12]=[CH:11][NH:10][C:7]2=[N:8][CH:9]=1)[CH3:2].[N+:14]([O-])([OH:16])=[O:15]>>[CH2:1]([O:3][C:4]1[C:5]([F:13])=[C:6]2[C:12]([N+:14]([O-:16])=[O:15])=[CH:11][NH:10][C:7]2=[N:8][CH:9]=1)[CH3:2]

参加物

反応物 2

HCID 944Nitric Acid

HCID 60205637HCID 60205637、化合物

生成物 1

HCID 602056385-ethoxy-4-fluoro-3-nitro-1H-pyrrolo[2,3-b]pyridine収率 78%

反応条件

温度: 0 °C

実験手順

Cold (about 0 to about 5° C.) fuming nitric acid (10 mL) was added to 5-ethoxy-4-fluoro-1H-pyrrolo[2,3-b]pyridine (340 mg, 0.944 mmol). The reaction was stirred at 0° C. for 15 minutes and then ice was added. The resulting solid was filtered and dried to yield 5-ethoxy-4-fluoro-3-nitro-1H-pyrrolo[2,3-b]pyridine (165 mg, 78% yield) as a solid.

後処理

additionice was added
filtrationThe resulting solid was filtered
customdried

出典と根拠

ORDレコード: ord-f28dc064195844e091f4e6007fc88506
出典データセット: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08545897B2

反応ノート

読み込み中…

参加物