Sodium borohydride → 1-(5,6-Dichloro-pyridin-3-yl)-ethanol
反応式
[BH4-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([C:11](=[O:13])[CH3:12])[CH:7]=[N:8][C:9]=1[Cl:10]>CO>[Cl:3][C:4]1[CH:5]=[C:6]([CH:11]([OH:13])[CH3:12])[CH:7]=[N:8][C:9]=1[Cl:10]参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a well stirred suspension of sodium borohydride (66.21 g, 1.75 mole) in methanol (3.5 L) cooled to 0° C. with a dry ice/acetone bath was added 1-(5,6-dichloro-pyridin-3-yl)-ethanone 8 (665 g, 3.5 mole) at a rate such that the temperature remained at 0° C. After solid addition was complete, the reaction mixture was stirred an additional 1 h, after which time LC/MS analysis of an aliquot showed that the reaction was complete.
後処理
- customremained at 0° C
- additionAfter solid addition
- stirringthe reaction mixture was stirred an additional 1 h
出典と根拠
- ORDレコード
- ord-f5d19051c95a48cf974f6492c4af2e2a
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08546388B2
反応ノート
読み込み中…